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Peritoneal mesothelioma clinical stage

By admin • Oct 19th, 2008 • Category: Peritoneal mesothelioma

Peritoneal mesothelioma for primary peritoneal mesothelial cell and the Organization of the tumor, clinical rare. Pathology can be divided into adenomatoid mesothelioma cystic mesothelioma and malignant mesothelioma (peritoneal malignant mesothelioma, PMM). The first two are benign. Cystic mesothelioma was particularly prevalent in women, the cause is unknown, occurred in the surrounding pelvic or annex, was single or multiple cystic masses; patients often palpable abdominal mass and treatment. Malignant peritoneal mesothelioma (PMM) account for about 30% of malignant mesothelioma; its occurrence and also closely related to asbestos exposure, about 5% of the patients have a history of exposure; asbestos fiber intake by mouth, through the intestinal wall to the translocation Peritoneal and pleural disease or from the transfer. Exposure to asbestos from the diagnosis, the disease incubation period of up to 25 to 40 years. However, from 1951 to 1993, domestic 20 reported 161 cases of PMM in only 1 case has a history of exposure to asbestos.Zhou Ya Kang, and other reports of 47 cases of mesothelioma in 8 cases of malignant peritoneal mesothelioma, as well as the author of the collection of 2 cases have a history of exposure to asbestos. No history of exposure to asbestos in the crowd, the incidence of about 1 / 1 million years, may be related to certain infections and genetic factors. Foreign PMM reported 1 case of a patient more than 40 years ago have come into contact with glial thorium dioxide (Thorotrast). PMM often occurred in men over the age of 40.Visceral or parietal peritoneum and the incidence may be; direct violation of abdominal tumor, pelvic organs; 50% to 70% of patients with lymphatic and / or metastasis of liver, kidney, adrenal gland, lung, bone, and so on.

PMM lack of specific clinical manifestations, abdominal pain, constipation, bloating, weight loss and other intestinal obstruction performance. Physical examination can be found ascites or peritoneal mass, and so on. For ascites effusion, as part of the blood. his disease misdiagnosed as tuberculosis peritonitis, recurrent spontaneous peritonitis, inflammation of superior mesenteric or peritoneal metastases, and so on. Ascites hyaluronic acid increased significantly greater than 0.8g / L were only found in the PMM. Ascites cells off inspection of some value there, but often difficult to judge.Serum carbohydrate antigen -125 (CA125) increased to help diagnose this disease.

Clinical stage: Butchart, and other PMM will be divided into 4: I view confined to the peritoneal tumor; â…¡ period of intra-abdominal lymph node tumor; â…¢ period of tumor metastasis to the lymph nodes outside the abdominal cavity; â…£ period of distant metastasis. The above categories will help to choose treatment. PMM so far no effective standard treatment. Very poor prognosis, the survival period after diagnosis with a median of 1 year, 2-year survival than those less than 20%. The main cachexia or died of intestinal obstruction, and rarely the cause of death related to tumor metastasis.



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