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When medication should not eat grapefruit, this is only a few years ago, reports of foreign countries. Around 2067 before the United States Food and Drug Administration has published a booklet, the book cautions: ANTIALLERGICS patients were terfenadine, or other similar drugs diphenhydramine hydrochloride, the prohibition of drinking grapefruit juice. Especially in elderly patients, not to eat when taking grapefruit or drink grapefruit juice. Since previous studies have shown that: ANTIALLERGICS grapefruit and terfenadine interaction give rise to ventricular arrhythmia, and even fatal ventricular fibrillation.

Abroad in recent years there have been reports that lipid-lowering statin drugs and grapefruit should not eat the same, or will he plasma concentration of statins increased. In February 2005, the United Kingdom drugs again HKMA issued a warning not to serve patients with hypolipidemic drugs in medication during the eating grapefruit or drinking grapefruit juice. In fact, a few years ago, Canadian researchers on the University of Ontario study found that grapefruit juice with 1 cup serving sent a lipid-lowering drugs, “lovastatin,” the one with glasses of water than usual to send clothes, blood, “Lovastatin “The higher the concentration of 10 ~ 15 times, that is to say, even if the normal dose of medication, if at the same time ate grapefruit or drinking grapefruit juice, the result of excessive medication are equal, the same is likely to cause poisoning.

Pharmacologists have done overseas corresponding clinical trials, the purpose of observation of people at the grapefruit juice to drink after the medication, serum drug concentration and water What is the difference between compared. It was found that different people react differently grapefruit juice. If after drinking grapefruit juice medication, the plasma concentration than the water several times after the drug may increase to hundreds of times; if the grapefruit juice to drink again after the medication from time to time and found that grapefruit juice on serum concentration can increase the role of the persistence of 24 hours; only 3 to 7 days later, the role of grapefruit juice before gradually disappearing.Therefore, for safety reasons, taking the first 3 days and 6 hours after the medication should avoid eating grapefruit.

Subsequently, studies have also mentioned that the ingredients contained in grapefruit may also happen with other adverse effects of western medicine. At present, with the grapefruit should not consider the drug has the same service: (1) statin drugs, such as lovastatin, Xuezhikang, Zocor, Lipitor; (2), calcium antagonists, such as nifedipine, nimodipine nimodipine, nisoldipine, nimodipine music charge; (3) stability of drugs, such as estazolam, Jiale determined; (4) antihistamines such as terfenadine; (5) immunosuppressive agents, such as cyclosporine Su-.

Fresh grapefruit with drugs and can cause adverse reactions mentioned above, there is no home study is also reported. However, for safety reasons, the patient (especially the elderly) service at more than drugs, it is best Fresh grapefruit or better.