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In the United States Orlando meeting of the American Association for Cancer Research annual meeting, the United States in Philadelphia’s Fox Chase Cancer Center researchers have proposed a new study, pain drugs such as aspirin, ibuprofen, Celebrex and Vioxx can help The prevention of ovarian cancer, the common anti-inflammatory drugs can inhibit cox-2 enzyme, may be able to slow down in ovarian cells of the dramatic changes rapidly and can be generated to reduce the potential risk of malignant cells.

The study leader Xiang-Xi (Mike) Xu, said, cox-2 enzyme had an impact

Cheng is an unusual mechanism.When we published the study, people said that the reason is obvious, but no one has previously found that this mechanism.

In comparison, ovarian cancer is rare, but it has a high mortality rate because ovarian tumors were not found until the cancer usually has spread to other organs, have not been discovered. For the United States women, ovarian cancer has become the fifth-largest cancer killer, about 15,000 people have been killed.

In this study, the research focus on the initial tumor in the ovary of what position. Dr. Xu explained that 90% of the cancers, including ovarian cancer, from the Organization of the cell surface layer that epithelial cells, which in the collagen of a “network” - in the basement membrane, line up one by one. When the laboratory for the analysis of ovarian epithelial cells, the researchers found that over-expression of cox-2 enzyme would seriously damage the cell membrane. Damage to the basement membrane of epithelial cells will have a negative impact on the life cycle, will speed up the mutation, or precursor cells to accumulate and increase the risk of cancer.

People already know, cox-2 will lead to inflammation, but also indirectly lead to headaches or joint pain.Non-steroidal anti-inflammatory drugs such as aspirin, ibuprofen may block the cox-1 and the cox-2 enzyme, and the new treatment of arthritis drug Celebrex and Vioxx only by reducing the cox-2 to alleviate the pain ( cox-1 enzymes also protect the stomach endometrium, as Celebrex and Vioxx do not inhibit it, as was the treatment of gastrointestinal diseases, prescription drugs).

Food and Drug Administration has approved these drugs for the prevention of colorectal cancer drug, a number of studies have suggested that these drugs can help reduce women’s risk of breast cancer risk.

Dr. Xu that, cox-2 inhibitors can reduce the damage of the basement membrane of the enzyme to help to prevent ovarian cancer. In addition to the elimination of inflammation, cox-2 in our body also has other functions, including stimulating ovulation. When ovulation, the basement will be clear now know that a number of female ovulation, the more she suffering from ovarian cancer risk greater. Of course, women in their lifetime due to pregnancy, breast-feeding or taking birth control drugs may reduce the risk of suffering from ovarian cancer.

Dr. Xu said the whole, to reduce any activity of cox-2 drugs would reduce the risk of suffering from ovarian cancer.

American Cancer Society, breast and gynecological cancer, said Dr. Debbie Saslow, director, found that ovarian tumor mechanism to provide for the “new information”, but the study is still in the stage of basic research.

At the same time, the research team plans to conduct a population-based studies, mainly because of family history and risk of ovarian cancer in high-risk women with ovarian their organizations to change the situation.The researchers collected as well as the use of non-use of non-steroidal anti-inflammatory drugs, women’s cells. Dr. Xu said that by comparing, we should first study whether there are any ovarian organizational change.

Dr. Saslow said, a variety of detection is awaiting U.S. Food and Drug Administration approval process.Each has been approved by the effective detection is still too early, there are still many important things.