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Are also smegma that are currently in the role of cholesterol by the bacteria can be transformed into carcinogens. Also lead to cervical cancer an important incentive. In recent years, also found that cervical cancer and some of the sexual transmission of HIV and to a certain extent, such as: â‘  human HSV-â…¡ (HSV-2), as a result of HSV-2 antibody screening in patients with invasive cervical cancer in 80% 100% positive; â‘¡ human papilloma virus (HPV), organizations of all types of HPV cervical cancer-specific antigen test, are indications of the incidence of cervical cancer and HPV infection; â‘¢ human cytomegalovirus (CMV). At home and abroad have reported that cervical precancerous lesions of atypical hyperplasia in patients with CMV antibody titers were high; animal experiments proved that CMV-DNA has the ability to malignant transformation. As a result, become infected with the virus causes cervical cancer research in recent years, one of the important issues.

Pathological changes

Cervical cancer with squamous cell carcinoma dominated, accounting for about 90% to 95%, cancer accounts for only 5% to 10%. However, both cancer in appearance is no special difference, and both occurred in the vaginal or cervical neck tube.

(I) in view of the development of invasive carcinoma, no special eye abnormalities, similar in general or cervical erosion. With the emergence of invasive carcinoma of the cervix may engage in the following four types:

1． Erosive: cervical around the outside I have a rough surface erosion of granular, or irregular Kuipo the face, bleeding easy to hit.

2．Exogenous type: also known as hyperplasia, or cauliflower-type. Polypoid from papillary or uplift, and then to the development of the vagina to highlight the size of the cauliflower-like vegetation, Yi Zhi Cui bleeding.

3．Endogenous type: also known as invasive. Deep cervical cancer invasion, cervical and hard-mast, but still smooth surface or only a superficial ulcer.

4．Ulcer type: whether endogenous or exogenous type to further develop after the cancer tissue necrosis off to form ulcers, and even the entire cervix is a big empty replaced, often as a result of secondary infection, so there is the stench of exhaust discharge. In particular, cervical cancer is also available to the neck tube growth, so that the cervix into a larger barrel, which is an endogenous type.

(B)-Cha

1．Atypical hyperplasia: dysplasia for the performance of the underlying cells, the cells not only the bottom of proliferation, and cell nuclei arranged in disorder and increase pollution concentration, and distribution chromatin inequality heterogeneous nuclear change.Atypical hyperplasia can be divided into light, medium and severe.

â‘  mild dysplasia (I-level inter-change): epithelial cells arranged in a little disorder, mild dysplasia cells, epithelial dysplasia hold on to the next one-third of the cortex.

â‘¡ moderate dysplasia (anaplastic grade â…¡): epithelial cells arranged in irregular shaped significantly, shaped the epithelial layer under the occupied two-thirds.

â‘¢ severe atypical hyperplasia (â…¢ level inter-change): almost all of epithelial polarity polar disorder or disappeared, significantly shaped cell carcinoma in situ and have been difficult to distinguish.

2．Carcinoma in situ: carcinoma in situ (CIS), also known as epithelial carcinoma. Full-thickness epithelial polarity disappeared, significantly shaped cells, nuclear, deep-dyed, uneven distribution of chromatin, with nuclear fission. But the disease remains confined to the cortex, did not penetrate the membrane, together infiltration.Cervical cells can also be shaped gland cavity along the transition zone into the open area of the cervical glands, causing glands of the original column for the multi-shaped cells replaced by squamous cells, but the gland is still intact basement membrane, called the situation For cervical carcinoma in situ gland involved.

3．Early invasive endoscopic: microscope in the early invasive carcinoma in situ basis, the chance of cancer cells can be found in the small college has pierced the basement membrane, like a teardrop-shaped membrane in the vicinity of the invasive mesenchymal, the depth of infiltration of not more than 5mm Wide, no more than 7mm, also cancer-free integration with each other and there were no violations of interstitial vascular indications, there is no clinical characteristics.

4．Squamous cell carcinoma: When the cancer cells penetrate the epithelial basement membrane, and violations of stromal depth of more than 5mm, known as squamous cell carcinoma. In the interstitial dendritic may occur, the cord-like, filled with cancer-like mass or nest. According to the pathology, differentiation of cancer cells can be divided into three levels:

â‘  I level: good differentiation. Cancer of nest there are a considerable number of keratosis, cancer of the beads can be seen clearly.

â‘¡ â…¡ level: Medium division (up to the middle cervical cell differentiation), the cancer nest is no keratosis.

â‘¢ â…¢ level: the small undifferentiated cells (equivalent to the bottom of the cervix undifferentiated cells).

5．Cancer: adenocarcinoma coating from the surface of the cervix, and tube neck glands within the columnar epithelium. Examination, they can see the structure of the gland, and even a cavity gland papillary protrusions.Epithelial hyperplasia to high-rise, low-rise cells, shaped obviously, can be seen with nuclear fission. If the gland cavity full of cancer cells, thus can not find the original structure of the gland, it is often difficult to be poorly differentiated adenocarcinoma and squamous cell carcinoma of the difference. Such as adenocarcinoma and squamous cell carcinoma of the cervix known as the co-exist when the gland, squamous cell carcinoma. Gland, with a high degree of malignant squamous cell carcinoma, the early shift, the worse the prognosis.