Love Health

November 17, 2008, a new study shows that there is a significant family history of the women, even if the gene found negative breast cancer-related genes, the risk of breast cancer are still higher than women in general.

This discovery may help doctors from high-risk women earlier in the screening of patients, and the sooner they take precautionary measures. University of Toronto professor Steven. Nailuo De said that he is the person in charge of the study.

People knew a long time ago, several friends and relatives suffering from breast cancer is a women will develop breast cancer for the assessment of the key considerations for Nailuo De said.

“We think that in general there are two women in the highest risk first, there is a family history of breast cancer, and the other is BRCA1, BRCA2 gene positive,” Nailuo De said, “but those positive family history, BRCA1, BRCA2 gene-negative women, They have the possibility of occurrence of breast cancer so much? No one can answer. The scientific community generally believed that these two mutations could explain the reasons for the majority. ”

The study found that in addition to BRCA1, BRCA2 genes outside of genes, hormones and other factors, such as the environment is likely to be risk factors for breast cancer, even if the BRCA1, BRCA2 gene negative.

“Since family history is so important, we must in fact they risk making accurate forecasts,” Nailuo De said, “It seems to me that this risk is so high, we have to make some interventions, such as a Laws for the MRI, used his to make Leiluoxifen preventive tamoxifen or chemotherapy. Our objective is really to prevent cancer, diagnosed at least as early as possible. ”

Kelly. Mankaerfu is also a professor at the University of Toronto, he said that “the risk of breast cancer among women, only 5% of the BRCA1, BRCA2 gene positive”, “For those of the gene-negative women, and they predict the risk for breast cancer How big a problem. ”

“If the BRCA1, BRCA2 gene positive, then her risk of breast cancer is 80 percent possibility,” said Mankaerfu, “for BRCA1, BRCA2 gene negative, positive family history of the women, we can predict now that she’s suffering from breast cancer The possibility is 40% of the general population of women suffering from breast cancer is the possibility of 10%. ”

Positive family history of female choice

The study found that (the study of immediate family members a total of 1492 women with breast cancer to participate) is as follows, Mankaerfu said: “BRCA1, BRCA2 gene mutation is the number one risk factor for breast cancer, but for those of the gene-negative , Positive family history of the women can not be taken lightly. ”

Nailuo De said he suggested that there are three or more relatives with breast cancer, BRCA1, BRCA2 gene-negative women in the law for the MRI, and to consider taking tamoxifen to prevent. The findings do not call people to do preventive removal of breasts, but he said there are fewer clinical requirements to do so many women.

“I think the community as a whole should take into account the deep,” said Nai Luode, “You can risk from 40% to 10%, which is already a great achievement, each of the risk of breast cancer is 40 % Of women should give serious consideration to this proposal. ”

But researchers say they do not recommend that all women have a family history of it all BRCA1, BRCA2 gene screening.

“Genes do not check an individual decision,” Mankaerfu said, “but there is a family history of the women, genetic screening could help predict their risk of breast and ovarian tumor the possibility of how much. If there are positive , Then medical intervention is the best choice. ”

University of Toronto study in the United States Tumor Institute of the seventh annual meeting of the “Cancer Prevention Research Symposium on the forefront,” published.

“I think if you are at high risk, taking tamoxifen, to carry out regular checks MRI, but you know, the scientific community needs more research.”

Danby. Sars (Debbie Saslow) in the United States Association of breast tumors and gynecologic oncology director of the Department, she said those negative inspection genes of women who are aware of their own is still at risk it is important.

She believes this part of the 30-year-old woman from the beginning to accept the academic image search, and to tell their doctor related to family history.

U.S. Oncology said that many clinical trials show that he and Mo Xi fun Leiluoxifen can reduce the risk of high-risk women.